JPEN J Parenter Enteral Nutr
May 2004
Background: The mechanism(s) responsible for the development of parenteral nutrition-associated liver disease (PNALD) is unknown. Recently, a number of bile canalicular transport proteins have been identified that transport bile components out of hepatocytes. One group of these genes, multidrug resistance 1 (mdr1) and mdr2, encode P-glycoproteins.
View Article and Find Full Text PDFForty-three neuroendocrine neoplasms were analyzed by immunohistochemistry for tyrosine hydroxylase and chrornogranin A and by in situ hybridization (ISH) for chrornogranin A messenger RNA (mRNA) using formalin-fixed paraffin-embedded tissue sections. These included pheochromocytomas (7), medullary thyroid carcinomas (5), small-cell lung carcinomas (5), olfactory neuroblastomas (5), neuroblastomas (10), ganglioneuroblastomas (5), and ganglioneuromas (6). Tyrosine hydroxylase was detected in all groups of tumors except the small-cell lung carcinomas, whereas immunoreactivity for chromogranin A protein was detected in all groups.
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