Publications by authors named "Kathleen M Stuebner"
Article Synopsis
- Osteosarcoma is a serious type of bone cancer that mainly affects kids and young adults, and it can be hard to treat with standard methods.
- Researchers tested a new treatment called VSV-IFNβ-NIS on dogs with the same cancer to see if it could help improve survival rates.
- The treatment seemed safe and showed promise, as about 35% of the treated dogs lived longer, and they also had signs of strong immune responses against the cancer.
Article Synopsis
- Osteosarcoma is a serious bone cancer that mostly affects kids, teens, and young adults, and even with treatment, some patients get worse.
- A new treatment using a special virus called VSV-IFNβ-NIS was tested on dogs with this type of cancer before they had surgery, and it showed promising results.
- The treatment was safe, helped some dogs live longer, and boosted their immune systems to fight cancer better.
Background: Canine osteosarcoma (OS) is a relevant spontaneous model for human OS. Identifying similarities in clinical characteristics associated with metastasis at diagnosis in both species may substantiate research aimed at using canine OS as a model for identifying mechanisms driving distant spread in the human disease.
Methods: This retrospective study included dog OS cases from three academic veterinary hospitals and human OS cases from the Surveillance, Epidemiology, and End Results program.
Article Synopsis
- A phase I study tested the safety of orally given SalpIL2 alongside amputation and doxorubicin chemotherapy in dogs with appendicular osteosarcoma.
- Six reportable adverse events occurred before chemotherapy, but none were linked to SalpIL2, indicating the treatment's safety.
- Dogs treated with SalpIL2 showed a significantly longer disease-free interval compared to those treated with doxorubicin alone, prompting further research into SalpIL2 as an adjuvant therapy.