In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial.

Objective: To determine whether performing comprehensive chromosome screening (CCS) and transferring a single euploid blastocyst can result in an ongoing pregnancy rate that is equivalent to transferring two untested blastocysts while reducing the risk of multiple gestation.

Design: Randomized, noninferiority trial.

Setting: Academic center for reproductive medicine.

Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder.

Objective: To evaluate the utility of trophectoderm biopsy for preimplantation genetic diagnosis (PGD) of mitochondrial (mt) DNA mutation load.

Design: A PGD case and analysis of blastocyst mosaicism.

Setting: Academic center for reproductive medicine.

Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting.

Objective: To assess the impact of oocyte vitrification on aneuploidy and reproductive potential by comparing vitrified and control oocytes from a single patient within a single cycle and a single fresh transfer.

Design: Paired randomized controlled trial in which each patient's cohort of mature oocytes was divided into two even groups with half undergoing Cryotop vitrification and rapid warming and half serving as controls.

Setting: Academic center for reproductive medicine.

Development and validation of an accurate quantitative real-time polymerase chain reaction-based assay for human blastocyst comprehensive chromosomal aneuploidy screening.

Objective: To develop and validate a quantitative real-time polymerase chain reaction (qPCR)-based method for blastocyst trophectoderm comprehensive chromosome screening (CCS) of aneuploidy.

Design: Prospective, randomized, and blinded.

Setting: Academic center for reproductive medicine.

Effect of infertility, maternal age, and number of previous miscarriages on the outcome of preimplantation genetic diagnosis for idiopathic recurrent pregnancy loss.

Objective: To determine whether preimplantation genetic diagnosis (PGD) would decrease spontaneous abortion rates in patients with idiopathic recurrent pregnancy loss (RPL).

Design: Controlled clinical study.

Setting: IVF center and PGD reference laboratory.