Publications by authors named "Kathleen M Bisset"
This research examines the in vitro interaction of phthalate diesters and monoesters with the G protein-coupled cannabinoid 1 (CB(1)) receptor, a presynaptic complex involved in the regulation of synaptic activity in mammalian brain. The diesters, n-butylbenzylphthalate (nBBP), di-n-hexylphthalate (DnHP), di-n-butylphthalate (DnBP), di-2-ethylhexylphthalate (DEHP), di-isooctylphthalate (DiOP) and di-n-octylphthalate (DnOP) inhibited the specific binding of the CB(1) receptor agonist [(3)H]CP-55940 to mouse whole brain membranes at micromolar concentrations (IC(50)s: nBBP 27.4 μM; DnHP 33.
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- The study investigated how two alkaloids (chelerythrine and sanguinarine) and two additional compounds (piperonyl butoxide and (S)-methoprene) interact with CB(1) receptors in mouse brains, showing that the alkaloids inhibit CB(1) receptor activity at low micromolar concentrations.
- Chelerythrine and sanguinarine were identified as effective antagonists, differing in action from a common blocker (AM251) and suggesting a unique mechanism involving the G-protein component.
- The findings indicate that while the investigated compounds are less potent than typical CB(1) blockers, they may provide a foundation for developing new and more effective receptor antagonists.