Publications by authors named "Kathleen Lange"

Background: Health professionals are increasingly called upon and willing to engage in planetary health care and management. However, so far, this topic is rarely covered in medical curricula. As the need for professional communication is particularly high in this subject area, this study aimed to evaluate whether the objective structured clinical examination (OSCE) could be used as an accompanying teaching tool.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how immunomodulator comedication can help reverse loss of therapeutic response (LOR) to TNF inhibitors in patients with inflammatory bowel disease (IBD) who have developed anti-drug antibodies (ADA).
  • Out of 123 IBD patients analyzed, those who received immunomodulator comedication showed significantly better outcomes in regaining clinical remission and clearing ADA compared to those who only had their TNF inhibitor doses increased.
  • The findings suggest that adding immunomodulators like azathioprine or methotrexate significantly improves the chances of maintaining effective treatment in IBD patients experiencing LOR due to ADA.
View Article and Find Full Text PDF

Mesalamine and topical or systemic corticosteroids form the basis of medicinal treatment of patients with chronic inflammatory bowel diseases (IBD), whereas immunosuppressants, biologicals and JAK inhibitors, so-called small molecules, are administered within so-called step-up treatment algorithms. Even though the frequency of operations has decreased during the last decades, surgical interventions still represent a relevant part of the overall concept in IBD treatment. Therefore, the effects of drug pretreatment on surgical approaches have to be put into specific perspectives and contexts.

View Article and Find Full Text PDF

We here describe a new approach to visualise nitric oxide (NO) in living macrophages by fluorescent NO-sensitive microspheres based on poly(lactic--glycolic acid) (PLGA). PLGA microspheres loaded with NO550 dye were prepared through a modified solvent-evaporation method. Microparticles were characterized by a mean hydrodynamic diameter of 3000 nm, zeta potential of -26.

View Article and Find Full Text PDF

The gut microbiota influences essential human functions including digestion, energy metabolism, and inflammation by modulating multiple endocrine, neural, and immune pathways of the host. Its composition and complexity varies markedly across individuals and across different sites of the gut, but provides a certain level of resilience against external perturbation. Short-term antibiotic treatment is able to shift the gut microbiota to long-term alternative dysbiotic states, which may promote the development and aggravation of disease.

View Article and Find Full Text PDF

Purpose: The presence of multidrug resistance-associated protein (MRP) in cancer cells is known to be responsible for many therapeutic failures in current oncological treatments. Here, we show that the combination of different effectors like hyperthermia, iron oxide nanoparticles, and chemotherapeutics influences expression of MRP 1 and 3 in an adenocarcinoma cell line.

Methods: BT-474 cells were treated with magnetic nanoparticles (MNP; 1.

View Article and Find Full Text PDF