Publications by authors named "Kathleen L Brown"
Article Synopsis
- - SARS-CoV-2 has infected over 340 million people, leading to research on therapies and studying genetic factors related to susceptibility and severity of COVID-19.
- - Genetic studies indicated that genetic factors account for 33% to 70% of SARS-CoV-2 susceptibility, while heritability for severity (measured by hospitalization duration) stood at 41%.
- - The findings suggest that understanding the genetic influence on COVID-19 is complicated by changing environments and vaccine effects during the pandemic, indicating a need for more research.
Regulation of transcript structure generates transcript diversity and plays an important role in human disease. The advent of long-read sequencing technologies offers the opportunity to study the role of genetic variation in transcript structure. In this Article, we present a large human long-read RNA-seq dataset using the Oxford Nanopore Technologies platform from 88 samples from Genotype-Tissue Expression (GTEx) tissues and cell lines, complementing the GTEx resource.
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