Publications by authors named "Kathleen Klotz-Noack"
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Synopsis of recent research by authors named "Kathleen Klotz-Noack"
- Kathleen Klotz-Noack's recent research focuses on the molecular mechanisms and vulnerabilities associated with colorectal cancer (CRC), particularly the roles of specific oncogenes such as NRAS and BRAF, and signaling pathways like the mitogen-activated protein kinase (MAPK) pathway.
- Through various experimental approaches, including single-cell transcriptome analysis and shRNA screens, Klotz-Noack has identified crucial transcriptional states, genetic mutations, and synthetic lethal interactions that contribute to tumor progression and resistance to therapies in colorectal cancer cells.
- Her studies emphasize the potential for targeted therapies that exploit the unique vulnerabilities of KRAS and NRAS mutant CRC cells, particularly through combinations of inhibitors that disrupt key signaling cascades and replication processes, highlighting new avenues for treatment in this challenging cancer type.
