Mononuclear Aluminum-Fluoride Ions, AlF-Study of Plausible Frameworks of Complexes with Biomolecules and Their In Vitro Toxicity.

The importance of fluorine and aluminum in all aspects of daily life has led to an enormous increase in human exposure to these elements in their various forms. It is therefore important to understand the routes of exposure and to investigate and understand the potential toxicity. Of particular concern are aluminum-fluoride complexes (AlF), which are able to mimic the natural isostructural phosphate group and influence the activity of numerous essential phosphoryl transferases.

Why are the Elemental Nonmetals (F , Cl , Br , I , S , P ) of so Many Hues or of Any Hues and Where is the Chromophore? Insight into Intera-X-X Bonds.

A unique approach is used to relate the HOMO-LUMO energy difference to the difference between the ionization potential (IP) and electron affinity (EA) to assist in deducing not only the colors, but also chromophores in elemental nonmetals. Our analysis focuses on compounds with lone pair electrons and σ electrons, namely X (X = F, Cl, Br, I), S and P . For the dihalogens, the [IP - EA] energies are found to be: F (12.

How Often are Orphan Drugs Orphaned by the Thermochemical Community?

Orphan drug products (e.g. drugs and biologics) in the United States are those that treat people with rare chronic diseases, often cancer or metabolic disease.

An overview of the understanding of ions containing solely fluorine atoms.

We discuss in the current paper ions containing solely fluorine atoms, F-, F2- and F3-, their corresponding cationic and/or multiply charged counterparts. While the emphasis of the paper is on gas phase species, their energetics and reactions, aqueous solutions are also discussed. In particular, biomedical and analytical aspects of F- are also considered.

Promoting quality improvement and achieving measurable change: the lead states initiative.

Along with the development of a national voluntary accreditation program for public health departments that holds quality improvement as its core goal, the application of quality improvement in public health has been gaining momentum. The 16 states participating in the Multi-State Learning Collaborative: Lead States in Public Health Quality Improvement (MLC) represent best practices in these activities. The MLC brings together partnerships in 16 US states to prepare for accreditation and implement quality-improvement practices.