Mentoring Models to Support Transition to Practice Programs: One Size Does Not Fit All.

One-on-one mentoring is not a fit for all transition to practice programs because of the need to recruit large numbers of mentors several times a year and the cost associated with supporting many mentor/mentee relationships. A group mentoring model is sustainable because it can foster a collaborative learning environment and emphasize knowledge sharing, skill acquisition, and emotional support within the group dynamic. Models can be replicated and applied in any setting.

Inclusion of Implicit Bias in Health Equity Education Design: A New Mandate for Continuing Education.

The area of implicit bias and health equity training is a renewed focus for health care settings. This article outlines a strategic journey to evaluate the current status and develop a sustainable program that integrates content on implicit bias and health equity into all training and education programs. Partnership with the health system's diversity department, professional development, and the use of innovative technology brought 100% compliance for the 12-month project.

eBooks: A Novel Approach to Education and Training Offering Savings and Resources.

eBooks can be an essential tool in bringing in technology-enriched education, just-in-time resources, and enduring material for staff in the health care setting. eBooks provide the most relevant information and can serve as the central hub for links to important documents, such as policies and/or video demonstrations. The use of eBooks will improve training and educational efficiency and can result in cost savings and improvements in standardized clinical practice.

Establishing a Virtual Learning Center: An Essential Platform to Support Technology-Forward Education.

A virtual learning center is the hub for storing enterprise teaching material where the information is immediately accessible and available to staff. Building and maintaining a virtual learning center requires collaboration with information technology staff, creative leaders, and tech-savvy nursing professional development specialists willing to innovate. Outcomes include cost savings, more standardized practice, and improved patient outcomes.

From Chaos to Control: One-Page Tip Sheet, a Nursing Professional Development Specialist's Essential Tool for Just-in-Time Education.

The speed of change in health care dictates that information and education must be rapidly disseminated. One-page tip sheets summarize and highlight the most important information at the point of care and provide links to further resources. The nursing professional development specialist plays a key role in facilitating and enabling rapid organizational change.

Implementation of a Hearing Loss Screening Intervention in Primary Care.

Purpose: Hearing loss (HL) is underdiagnosed and often unaddressed. A recent study of screening for HL using an electronic prompt showed efficacy in increasing appropriate referrals for subsequent testing. We build on the results of this study using a qualitative lens to explore implementation processes through the perspectives of family medicine clinicians.

The Show Must Go On: Using Technology for Rapid Onboarding and Orientation During COVID-19 and Beyond.

The global pandemic presented an opportunity for using technology in expanded ways to meet mandated restrictions posed by the crisis. Nursing professional development practitioners redesigned onboarding structures and curriculum to accommodate the surge of new hires, taking into consideration restrictions set forth by regulatory institutions. Mobile technology and virtual learning were the platform used for this innovative approach.

Game Changer: Integrating Technology to Bring Competency and Policy to Life.

Using technology can transform methodologies for staff education and clinical practice while addressing different learning styles and competency needs. Video can enhance competency standardization and policy use. Videos increase staff engagement and level of confidence when supplementing clinical education and policy management.

Just-in-Time Learning and QR Codes: A Must-Have Tool for Nursing Professional Development Specialists.

Technology can and will transform staff development. Tools such as quick response (QR) codes enable immediate and just-in-time access when staff need information or training material. Understanding the how and why of QR code use is the first step.

Efficacy and Tolerability of STOPAIN for a Migraine Attack.

Objective: To determine whether topical menthol 6% gel will relieve a migraine attack.

Materials And Methods: A single-center, open-label pilot trial of 25 patients with at least 1 year of diagnosed episodic migraine and <15 headache days per month. Patients treated one migraine attack with STOPAIN topical menthol 6% gel to skull base within 2 h of headache onset.

Duloxetine prophylaxis for episodic migraine in persons without depression: a prospective study.

Objective: The objective of this pilot study is to evaluate the effects of daily duloxetine, 60-120 mg, on the frequency, duration, and severity of migraine attacks and the level of disability in episodic migraineurs.

Background: There is a need for more proven effective migraine preventive medications. Two antidepressants, both of which block serotonin and norepinephrine reuptake, have been shown to be effective in the preventive treatment of migraine.

Breaking news: implementing fun methods for keeping nurses informed.

This column describes an innovative technique for keeping direct care nurses up-to-date.

Dihydroergotamine for early and late treatment of migraine with cutaneous allodynia: an open-label pilot trial.

Objective: To explore whether dihydroergotamine (D.H.E.

An isolated intracardiac echogenic focus as a marker for aneuploidy.

Objective: This study was undertaken to evaluate the relationship of an isolated fetal intracardiac echogenic focus in a population of patients with a mixed risk for aneuploidy when presenting for prenatal diagnosis.

Study Design: All women referred to our institution for screening ultrasound were prospectively evaluated for the presence of an intracardiac echogenic focus in the fetal heart. Each patient was evaluated for the presence of clinical risk factors including ultrasound findings, biochemical screening, and maternal age.

Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo.

Over 1 billion monocytes are produced daily, with a small percentage differentiating into macrophages, suggesting that excess monocytes are deleted through a tightly regulated process. Although the in vivo mechanism governing monocyte/macrophage homeostasis is unknown, deletion of monocytes in culture is mediated by the Fas death pathway and is blocked by M-CSF. To determine the in vivo significance of Fas in monocyte development, mice lacking Fas (lpr/lpr) and mice deficient in Fas and M-CSF were examined.

IL-4 and IL-10 inhibition of spontaneous monocyte apoptosis is associated with Flip upregulation.

Human peripheral blood monocytes undergo spontaneous apoptosis in culture. Spontaneous monocyte apoptosis is regulated by the death ligand, Fas Ligand (FasL) binding to its receptor Fas. The pro-inflammatory molecules, LPS and IL-1beta, prevent spontaneous monocyte apoptosis.

A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway.

Abrogation of ubiquitin/proteasome-dependent turnover of p53 is critical for its activation. UbL-UBA proteins, including human homolog of Rad23 (hHR23) proteins, may regulate proteasomal degradation of substrates such as p53, due to their ability to interact with both ubiquitinated substrates and the proteasome. siRNA-mediated depletion of hHR23A or hHR23B in human cell lines accelerated p53 degradation.

Consecutive transcranial magnetic stimulation: phosphene thresholds in migraineurs and controls.

Objective: To characterize the temporal course of transcranial magnetic stimulation-induced phosphene thresholds in subjects with migraine and in controls.

Methods: Eleven subjects with migraine with aura, 10 subjects with migraine without aura, 9 subjects with menstrual migraine, and 15 controls (no history of migraine and without migraine during the study) were studied. Subjects were not on preventive medication.

Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts.

Objective: Rheumatoid arthritis (RA) is characterized by increased synovial lining cellularity, inflammation, and destruction of cartilage and bone. During the pathogenesis of RA, synovial fibroblasts reenter the cell cycle and multiply in number. RA synovial fibroblasts express high levels of the MAP kinase p38, which may contribute to the production of interleukin-6 (IL-6) and matrix metalloproteinases (MMPs).

IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts.

During the pathogenesis of rheumatoid arthritis (RA), the synovial fibroblasts increase in number and produce proinflammatory cytokines and matrix metalloproteinases (MMPs) that function to promote inflammation and joint destruction. Recent investigations have suggested that cell cycle activity and inflammation may be linked. However, little is known about the mechanisms responsible for the coordinate regulation of proliferation and the expression of proinflammatory molecules in RA synovial fibroblasts.