Publications by authors named "Kathiravan Ramaiyan Selvaraju"
Whole genome sequencing and comparative genomics of isolated from different animal hosts to identify specific diagnostic markers.
Front Cell Infect Microbiol
January 2024
Article Synopsis
- * Researchers isolated and sequenced genomes from 9 animal samples (4 cattle, 4 deer, and 1 buffalo) that died from tuberculosis and compared them to existing data, revealing a closed pangenome structure and a unique SNP in a virulence gene as a potential identification marker.
- * The findings indicate that this specific MTBC member is prevalent in South Asian animals, highlighting its zoonotic potential and the need for further evaluation of its impact on animal and human health.
The Bacillus Calmette-Guérin (BCG) vaccination provides partial protection against, and reduces severity of pathological lesions associated with bovine tuberculosis (bTB) in cattle. Accumulating evidence also suggests that revaccination with BCG may be needed to enhance the duration of immune protection. Since BCG vaccine cross-reacts with traditional tuberculin-based diagnostic tests, a peptide-based defined antigen skin test (DST) comprising of ESAT-6, CFP-10, and Rv3615c to detect the infected among the BCG-vaccinated animals (DIVA) was recently described.
View Article and Find Full Text PDFIn most low- and middle-income countries (LMICs), bovine tuberculosis (bTB) remains endemic due to the absence of control programs. This is because successful bTB control and eradication programs have relied on test-and-slaughter strategies that are socioeconomically unfeasible in LMICs. While Bacillus Calmette-Guérin (BCG) vaccine-induced protection for cattle has long been documented in experimental and field trials, its use in control programs has been precluded by the inability to differentiate BCG-vaccinated from naturally infected animals using the OIE-prescribed purified protein derivative (PPD)-based tuberculin skin tests.
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