Publications by authors named "Kathia Abdoun"
Article Synopsis
- Bicuspid aortic valve (BAV) shows increased progression of aorta dilation compared to tricuspid aortic valve (TAV) in patients with aortic stenosis, with a median annualized change of 0.33 mm/year for BAV versus 0.21 mm/year for TAV.
- Factors influencing the dilation rate differ by valve type; BAV patients are more affected by low-density lipoprotein (LDL) levels, while TAV patients are influenced by the apolipoprotein B/A-I ratio and baseline aortic jet velocity.
- The study highlights that men and women have different predictors for AA dilation; men’s dilation relates to baseline jet velocity and aortic diameter, while
Background: Little is known about the effect of sex on functional status decline in aortic valve stenosis (AS) patients.
Objectives: The purpose of this study was to examine the changes in functional status according to sex in patients with mild-to-moderate AS and its association with the composite of death or aortic valve replacement (AVR).
Methods: We included patients with mild-to-moderate AS prospectively recruited in the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study (NCT01679431).
Calcific aortic stenosis (AS) is a major cause of morbidity and mortality in high-income countries. AS presents sex-specific features impacting pathophysiology, outcomes, and management strategies. In women, AS often manifests with a high valvular fibrotic burden, small valvular annuli, concentric left ventricular (LV) remodeling/hypertrophy, and, frequently, supernormal LV ejection fraction coupled with diastolic dysfunction.
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- There are currently no drugs available to slow the progression of aortic stenosis, and while plasma lipoprotein(a) levels may predict its onset, their role in disease progression is debated.
- A study involving 710 patients from Canada and the UK examined the relationship between plasma lipoprotein(a) concentrations and hemodynamic changes in aortic stenosis.
- Results showed that patients with higher lipoprotein(a) levels experienced significantly faster progression in peak aortic jet velocity and mean transvalvular gradient, suggesting that elevated lipoprotein(a) may contribute to worse outcomes in aortic stenosis patients.