Publications by authors named "Katheryn M Wininger"
Article Synopsis
- - Concerns about neurotoxic effects of gadolinium retention from contrast agents have increased global scrutiny, but the clinical implications of this retention are still unclear.
- - A study involved 183 male rats receiving multiple doses of different gadolinium-based contrast agents (GBCA) to evaluate behavioral changes and the effects of gadolinium retention.
- - Results showed no significant behavioral differences between treated and control rats, but higher gadolinium levels were found in the brains of rats given linear GBCAs; clearance of gadolinium varied by agent, with some showing substantial removal over time.
Acamprosate is an FDA-approved medication for the treatment of alcoholism that is unfortunately only effective in certain patients. Although acamprosate is known to stabilize the hyper-glutamatergic state in alcoholism, pharmacological mechanisms of action in brain tissue remains unknown. To investigate the mechanism of acamprosate efficacy, the authors employ a pharmacoproteomics approach using an animal model of alcoholism, type 1 equilibrative nucleoside transporter (ENT1) null mice.
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