Publications by authors named "Katherine Talcott"

Background And Objective: This study aimed to analyze baseline predictors of visual response in patients with neovascular age-related macular degeneration (nAMD) who have undergone lapses in treatment with anti-VEGF therapy. The mainstay treatment option for nAMD is intravitreal vascular endothelial growth factor inhibitor (anti-VEGF) therapy. Given the chronic nature of nAMD, patients who undergo lapses in treatment with these agents can have progression of their disease.

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Purpose: The association between GLP-1 receptor agonists (GLP-1RA) and non-arteritic anterior ischemic optic neuropathy (NAION) remains unclear. Given the debilitating sequelae of NAION and rapid increase of GLP-1RA use, further research is essential to investigate this potential relationship. This study seeks to determine the risk of NAION and ischemic optic neuropathy (ION) in patients prescribed GLP-1RAs.

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Background/objectives: Data on the prevalence of optic neuritis (ON) is limited with reported rates between 5.5 and 115.3 per 100,000.

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Background: Fulminant idiopathic intracranial hypertension (IIH) is a rare presentation of IIH characterized by rapid visual loss. Little is known regarding the cause of fulminant IIH and how to treat this condition. We conducted an analytical study aimed at characterizing disease, treatment, and visual outcomes while evaluating the time and frequency of recurrence of papilledema.

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Purpose: To evaluate the short-term outcomes of patients with exudative neovascular age-related macular degeneration (nAMD) treated with high-dose aflibercept 8.0 mg (HDA), focusing on anatomical and functional changes, as well as the feasibility of extending treatment intervals in real-world clinical practice.

Design: Retrospective, noncomparative cohort study.

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Purpose: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have risen exponentially in usage and have been shown to exert neuroprotective and anti-inflammatory effects across multiple organ systems. This study investigates whether GLP-1RAs influence the risk for age-related ocular diseases.

Design: Retrospective cohort study.

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To evaluate the prevalence of geographic atrophy (GA) lesions in patients with a diagnosis of intermediate age-related macular degeneration (iAMD). A retrospective cross-sectional study was performed of patients with an International Classification of Diseases, 10th Revision, diagnosis of iAMD. The primary outcome was the percentage of eyes diagnosed with iAMD with an undocumented GA lesion identified on imaging.

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To evaluate the effect of antivascular endothelial growth factor (anti-VEGF) agents on the development of sustained intraocular pressure (IOP) elevations. This single-center retrospective cohort study included eyes receiving anti-VEGF injections for various indications along with nontreated fellow eyes from 2012 to 2022. Patients were grouped according to treatment with bevacizumab, ranibizumab, or aflibercept.

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To identify baseline characteristics that predict visual outcomes after a lapse in treatment among patients with diabetic macular edema (DME) who received intravitreal antivascular endothelial growth factor injections. In this retrospective study, patients with DME who had lapses in treatment of 3 months or longer were separated into 2 groups (stable vision, n = 201; vision loss, n = 61) based on an Early Treatment Diabetic Retinopathy Study vision loss threshold of 10 letters. Stepwise backward logistic regression was used to analyze baseline factors associated with vision loss and to create a predictive algorithm.

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Background/objectives: Patients with thyroid eye disease (TED) taking teprotumumab have reported audiologic symptoms as a side effect; however, limited real world data and large sample sizes have been utilized to evaluate this relationship.

Methods: A retrospective cohort study was created in TriNetX to identify patients with TED utilizing ICD-10, CPT, and Healthcare Common Procedure coding systems. TED patients with and without teprotumumab treatment were analysed with greedy one-to-one propensity matching.

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Article Synopsis
  • Idiopathic intracranial hypertension (IIH) primarily affects overweight or obese women of reproductive age, making it crucial to investigate its relationship with pregnancy.
  • A study examined the incidence of IIH development during pregnancy and its association with hypertensive disorders, finding that 7% of IIH patients experienced new onset IIH during their pregnancies.
  • IIH patients had significantly higher risks for various hypertensive disorders like eclampsia, preeclampsia, and HELLP syndrome, as well as complications like ectopic pregnancies and miscarriages, even when controlling for obesity and migraine factors.
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Article Synopsis
  • * A thorough search yielded 28 relevant studies, showing that DS is linked to unusual retinal characteristics, such as abnormal vascularization and thickening, which may increase retinal disease rates.
  • * From a large population analysis, 0.18% of individuals had a DS diagnosis, and those with DS displayed significantly higher odds ratios for various retinal disorders compared to those without DS, indicating a need for further research on this relationship.
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Purpose: The prevalence of central serous chorioretinopathy (CSCR) among transmasculine, polycystic ovary syndrome (PCOS), and androgen-exposed patients remains largely unexplored. Although these groups involve patients with elevated testosterone levels, previous literature is inconclusive on the influence of testosterone on CSCR. This study aimed to determine the relationship between CSCR and cohorts with exogenous androgen exposure, female-to-male (FTM) transgender individuals, and those diagnosed with PCOS.

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Background And Objective: Janus kinase (Jak) inhibitors may have increased risk of thromboembolism compared to tumor necrosis factor (TNF) inhibitors. This study investigates the association between Jak inhibitor use and retinal vein occlusion.

Patients And Methods: This retrospective, non-randomized cohort study used a federated health research network.

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Background And Objective: This study assesses long-term outcomes following surgical repair of idiopathic full-thickness macular holes (FTMHs) in patients with at least 5 years of postoperative follow-up.

Patients And Methods: A retrospective study evaluated patients diagnosed with idiopathic FTMH who received surgical repair at a single tertiary center with at least 5 years of postoperative follow-up. Data collection included demographic and preoperative characteristics along with macular hole structural integrity as determined by spectral-domain optical coherence tomography (OCT).

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Background And Objective: As the therapeutic efficacy of lipid-lowering agents (LLA) against diabetic retinopathy (DR) remains controversial, this study aimed to evaluate whether various LLA therapies are associated with a reduced risk of DR progression.

Patients And Methods: This retrospective study of the medical records of adults with type 2 diabetes mellitus and DR compared the risk of adverse progression of DR between patients who received statins, fibrates, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, and no LLA (control).

Results: Patients in the statin cohort had a reduced rate of progression to proliferative DR compared to controls (HR = 0.

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Since the Artificial Intelligence Committee of the American Society of Retina Specialists developed the initial task force report in 2020, the artificial intelligence (AI) field has seen further adoption of US Food and Drug Administration-approved AI platforms and significant development of AI for various retinal conditions. With expansion of this technology comes further areas of challenges, including the data sources used in AI, the democracy of AI, commercialization, bias, and the need for provider education on the technology of AI. The overall focus of this committee report is to explore these recent issues as they relate to the continued development of AI and its integration into ophthalmology and retinal practice.

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Article Synopsis
  • Tetracyclines and vitamin A derivatives, commonly used for acne and anti-aging, are linked to drug-induced intracranial hypertension (DIIH), but treatment practices and visual outcomes have not been well studied.
  • This study examined 839 patients diagnosed with IIH, finding that 8.10% developed DIIH, most of whom (83%) were using medication for acne, predominantly females with an average age of about 25.
  • Only 3 patients experienced poor visual outcomes, and they all used vitamin A derivatives; the study emphasizes the need for immediate intervention if headaches or visual changes occur in patients taking DIIH medications.
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Silicone oil (SO) is commonly used as a retinal tamponade during pars plana vitrectomy for complicated retinal detachments. Although fairly inert, complications such as cataract formation, intraocular pressure elevation, corneal changes, inner retinal thinning, and optic neuropathy have been noted. We report two cases of postoperative subfoveal outer retinal lucency and hyperreflective deposits following SO insertion and resolution following removal.

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Article Synopsis
  • Vision loss is a significant disability in the US, and this study aimed to understand the impact of various ocular diseases, demographic factors like sex and race, on the risk of visual impairment.
  • The analysis utilized data from over 90 million patients, focusing on conditions such as diabetic retinopathy, macular degeneration, and glaucoma, identifying those most at risk based on comorbidities and demographics.
  • Results showed that uveitis combined with retinal vein occlusion posed the highest risk for visual impairment, with Black and Hispanic males experiencing a disproportionate incidence compared to white males.
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This study aimed to assess retinal alterations following membrane peeling procedures using novel ILM Forceps with laser ablated surface with the help of intraoperative optical coherence tomography (iOCT). A post-hoc analysis was performed to evaluate iOCT findings in eyes that underwent membrane peeling procedures with the novel ILM Forceps. Pre-peel and post-peel iOCT videos and images were evaluated for each eye to assess for post-peel anatomic alterations.

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Objective: To determine if differences exist in the risk of developing large vessel retinal vascular occlusions in patients with sickle cell states.

Design: Retrospective cohort study.

Participants: Patients with sickle cell disease (SCD) or trait evaluated by an ophthalmologist were compared with matched controls without SCD or sickle cell trait (SCT) also evaluated by an ophthalmologist.

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Fulminant idiopathic intracranial hypertension (IIH) is a rapid vision-degrading presentation of IIH with limited published studies. This study composed a narrative review of fulminant IIH with the aim of better characterising fulminant IIH presentation and visual outcomes. SCOPUS and PubMed were searched for papers referencing IIH, benign intracranial hypertension, or pseudotumour cerebri.

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