Association between Psoriasis and MTHFR polymorphisms: a systematic review and meta-analysis.

Methylenetetrahydrofolate reductase (MTHFR) is key to the metabolism of folic acid, with loss of function mutations resulting in elevated homocysteine levels, a known risk factor for cardiovascular disease. Psoriasis patients may demonstrate hyperhomocysteinemia. To assess for the association between psoriasis and MTHFR C677T and A1298C polymorphisms.

Alternative uses of ustekinumab for non-indicated dermatological conditions: a systematic review.

Ustekinumab is approved for the treatment of psoriasis and Crohn's disease. Because many dermatological conditions are due to immune-mediated development, ustekinumab may be effective in other conditions. A systematic review of the off-label uses of ustekinumab, as well as on-label adverse effect, was performed, reporting on clinical improvement.

Circumscribed palmoplantar hypokeratosis: a case report and review of the literature.

We describe an 84-year-old man presenting with a solitary, well-circumscribed, chronic erosion of the sole. Histopathologic examination confirmed diagnosis of circumscribed palmoplantar hypokeratosis. Circumscribed palmoplantar hypokeratosis is a rare and benign condition of unknown etiology presenting as an erosion on the palms or soles.

Mycobacteria infection in an immunocompetent patient with no risk factors: evaluation and management of non-healing majocchi granuloma-type nodule.

Atypical mycobacterial infections are more commonly described among immunocompromised patients, although there has been an increasing incidence in recent years of infections in immunocompetent hosts. Normally preceding trauma is a risk factor for infection. We describe a case of Mycobacteria chelonae infection in a healthy individual with no risk factors.

The significance of crystalline/chrysalis structures in the diagnosis of melanocytic and nonmelanocytic lesions.

Background: Crystalline/chrysalis structures (CS) are white shiny streaks that can only be seen with polarized dermatoscopy.

Objectives: We sought to estimate the prevalence and assess the clinical significance of CS in melanocytic and nonmelanocytic lesions.

Methods: This was a prospective observational study in which dermatoscopic assessment of lesions was recorded in consecutive patients examined during a 6-month period.

Accuracy in melanoma detection: a 10-year multicenter survey.

Background: Early excision is the only strategy to reduce melanoma mortality, but unnecessary excision of benign lesions increases morbidity and healthcare costs.

Objective: To assess accuracy in melanoma detection based on number-needed-to-excise (NNE) values over a 10-year period.

Methods: Information was retrieved on all histopathologically confirmed cutaneous melanomas or melanocytic nevi that were excised between 1998 and 2007 at participating clinics.

The impact of physician screening on melanoma detection.

Objective: To compare melanoma characteristics and detection patterns in new vs established patients in a pigmented lesion clinic at Memorial Sloan-Kettering Cancer Center (MSKCC) during a 10-year period.

Design: Single-center historical cohort study.

Setting: Academic practice of 2 dermatologists with expertise in the management of pigmented skin lesions.