GlpR Is a Direct Transcriptional Repressor of Fructose Metabolic Genes in Haloferax volcanii.

DeoR-type helix-turn-helix (HTH) domain proteins are transcriptional regulators of sugar and nucleoside metabolism in diverse bacteria and also occur in select archaea. In the model archaeon , previous work implicated GlpR, a DeoR-type transcriptional regulator, in the transcriptional repression of and the gene encoding the fructose-specific phosphofructokinase () during growth on glycerol. However, the global regulon governed by GlpR remained unclear.