In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth.

Problem: Activated/effector T cells seem to play a role in the pathological inflammation associated with preterm labor. The aim of this study was to determine whether in vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth.

Method Of Study: Pregnant B6 mice were intraperitoneally injected with a monoclonal αCD3ε antibody or its isotype control.

Molecular mechanisms of reactive oxygen species-related pulmonary inflammation and asthma.

Asthma is a highly relevant disorder that can be induced by many environmental factors such as allergens and pollutants. One of the most critical pathological symptoms of asthma is airway inflammation. In order to identify a cause of respiratory inflammation, we thoroughly examine the unique role of reactive oxygen species (ROS).