Publications by authors named "Katherine R Thain"
A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases the amount of low-density lipoprotein (LDL) receptors on liver cells and, therefore, LDL clearance. The clearance of lipids from pathogens is related to endogenous lipid clearance; thus, PCSK9 may also regulate removal of pathogen lipids such as lipopolysaccharide (LPS). Compared to controls, Pcsk9 knockout mice displayed decreases in inflammatory cytokine production and in other physiological responses to LPS.
View Article and Find Full Text PDFIntroduction: Genetic variation in the Protein C gene (PROC) is associated with altered risk of adverse outcome for a number of diseases. Common single nucleotide polymorphisms (SNPs) in the promoter region and the adjacent 5' region of PROC are associated with Protein C expression. We tested the hypothesis that common SNPs (minor allele frequency >10%) between the frequently studied promoter SNPs -1654 (rs1799808) and -1641 (rs1799809), and the end of PROC intron 2 alter nuclear transcription factor binding.
View Article and Find Full Text PDFArticle Synopsis
- Vasopressin is a crucial hormone that helps regulate blood pressure and is sometimes used in treating septic shock.
- Researchers studied the relationship between specific genetic variations (SNPs) in vasopressin pathway genes and patient outcomes, focusing on 28-day mortality and vasopressin clearance in two groups (589 and 616 patients) and a third group related to serum sodium levels (977 patients).
- A notable SNP in the LNPEP gene (rs4869317) was linked to higher 28-day mortality rates and increased vasopressin clearance, indicating that genetic factors can significantly influence patient survival and sodium balance in septic shock.
beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock.
Am J Respir Crit Care Med
January 2010
Rationale: The CysGlyGln haplotype of the beta(2)-adrenergic receptor gene (ADRB2) is functional and associated with altered responses to adrenergic agonists in patients with asthma. Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown.
Objectives: To determine whether genetic variation of ADRB2 influences outcome in septic shock.