Publications by authors named "Katherine R Leng"
J Biol Chem
December 2017
Article Synopsis
- Histone deacetylases (HDACs) remove acetyl groups from proteins, but their specificity has mainly been studied using peptide substrates, raising questions about how well these reflect their behavior with full-length proteins.
- Research comparing HDAC8's action on peptides, full-length proteins, and protein-nucleic acid complexes reveals that it works much more efficiently on full-length histones than on peptides, suggesting additional interactions boost its activity.
- However, as the size of protein complexes increases, the efficiency decreases, indicating that HDAC8 substrate selectivity relies on a blend of short- and long-range interactions with the substrates.
