Publications by authors named "Katherine Quensel"
Article Synopsis
- TGFbeta stimulates fibrogenic responses in fibroblasts, which involves reactive oxygen species (ROS) and the enzyme NADPH oxidase (NOX).
- The study investigates whether antioxidants like N-acetylcysteine (NAC) and NOX inhibitors like diphenyleneiodonium (DPI) and GKT-137831 can reduce TGFbeta-induced fibrogenic gene expression in human gingival and dermal fibroblasts.
- Results showed that NAC and DPI effectively impair TGFbeta-induced expression of certain fibrogenic proteins, while GKT-137831 diminishes these effects in both normal and scleroderma fibroblasts, suggesting these compounds could be potential antifibrotic treatments
