Publications by authors named "Katherine P Tong"
Article Synopsis
- * Research shows that allogeneic CD8 T cells have a unique presence and maintain a diverse T cell receptor profile during an immune response, despite not expressing some typical activation markers.
- * The study highlights the importance of activated CD43 and ICOS receptors in identifying effective CD8 T cell populations post-transplant, suggesting that targeting these can improve graft survival when combined with certain treatments.
Belatacept-based immunosuppression in kidney transplantation confers fewer off-target toxicities than calcineurin inhibitors but comes at a cost of increased incidence and severity of acute rejection, potentially due to its deleterious effect on both the number and function of Foxp3 regulatory T cells (Tregs). TIGIT is a CD28 family coinhibitory receptor expressed on several subsets of immune cells including Tregs. We hypothesized that coinhibition through TIGIT signaling could function to ameliorate costimulation blockade-resistant rejection.
View Article and Find Full Text PDFThe identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8 T pool is unexpectedly comprised of both CD45RB and CD45RB populations. Relative to CD45RB memory T cells, CD45RB memory T cells have lower affinity and display greater clonal diversity, as well as a persistent CD27 phenotype.
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