Publications by authors named "Katherine Myint-Hpu"
Article Synopsis
- Elderly patients with severe COVID-19 showed reduced T-cell diversity and weaker immune responses compared to younger patients, highlighting age-related vulnerabilities in fighting the virus.
- The study used advanced sequencing techniques to analyze T-cell responses in both COVID-19 patients and individuals with inborn errors of immunity who received an mRNA vaccine, revealing specific genetic associations affecting these responses.
- Findings indicated that mRNA vaccines successfully enhanced the T-cell responses in individuals with immune deficiencies, suggesting their effectiveness even in populations that struggle to develop strong immune responses on their own.
Article Synopsis
- The SASH3 protein is an adaptor involved in orchestrating signaling in lymphocytes, and its gene is located on the X-chromosome.
- Researchers found 3 harmful mutations in the SASH3 gene in 4 unrelated male patients who displayed symptoms of combined immunodeficiency and immune dysregulation, leading to infections and autoimmune issues.
- The study reveals that SASH3 is crucial for proper lymphocyte function and survival, suggesting a new form of X-linked combined immunodeficiency in humans similar to defects seen in mouse models.
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outcome remains elusive. Here, we analyzed levels of 66 soluble biomarkers in 175 Italian patients with COVID-19 ranging from mild/moderate to critical severity and assessed type I IFN-, type II IFN-, and NF-κB-dependent whole-blood transcriptional signatures.
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