Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin.

Background: QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes.

Methods: One case is described in which a patient with schizophrenia, who was being treated for dyslipidemia, developed a prolonged QTc interval while taking quetiapine and lovastatin.

Results: QTc returned to baseline when the lovastatin dose was reduced.