Overview of secondary immunodeficiency.

In contrast to inborn errors of immunity (IEI), which are inherited disorders of the immune system that predispose to infections, malignancy, atopy, and immune dysregulation, secondary immunodeficiencies and immune dysregulation states (SID) are acquired impairments in immune cell function and/or regulation, and may be transient, reversible, or permanent. SIDs can derive from a variety of medical comorbidities, including protein-losing conditions, malnutrition, malignancy, certain genetic syndromes, prematurity, and chronic infections. Medications, including immunosuppressive and chemotherapeutic drugs, can have profound effects on immunity and biologic agents used in rheumatology, neurology, and hematology/oncology practice are increasingly common causes of SID.

Novel systemic treatments in atopic dermatitis: Are there sex differences?

Atopic dermatitis (AD) is a common inflammatory skin disease with a significant global disease burden. Several mechanisms underlie AD, such as epidermal barrier dysfunction and immune dysregulation, which have led to innovative systemic treatment options. Other inflammatory disorders, as well as innate and adaptive immune responses, have noted sex differences, but our article highlights a paucity of data on the impact of sex, gender, and gender identity on the pathophysiology and systemic treatments of AD.

Capturing anaphylaxis through medical records: Are ICD and CPT codes sufficient?

Objective: The identification of anaphylaxis cases is imperative for optimal clinicalprovider knowledge deficiencies in diagnosis and treatment and the efficacy of reimbursement codes, such as International Classification of Diseases (ICD) and current procedural terminology (CPT) codes, in detecting anaphylaxis.

Data Sources: Pubmed.

Study Selections: Recent and clinically relevant literature on anaphylaxis and provider knowledge, ICD, CPT, Healthcare Common Procedural Coding System (HCPCS), and E-codes were selected and reviewed.

Ovomucoid specific immunoglobulin E as a predictor of tolerance to cooked egg.

Background: Ovomucoid is the dominant allergen in hen's egg. Although several studies evaluated the utility of ovomucoid specific immunoglobulin E (sIgE) levels in predicting baked (e.g.