Publications by authors named "Katherine L Joseph"
Article Synopsis
- The study used phase contrast and epifluorescence microscopy to examine how human astrocytoma cells changed when exposed to single-walled carbon nanotube (SWCNT) conjugates with different surfactants.
- Findings showed that the toxicity of the SWCNTs varied based on the surfactants used, with sodium dodecyl sulfate (SDS) significantly altering cell morphology and being toxic, while sodium cholate (SC) was safe for the cells.
- The research suggests that SWCNTs, especially when paired with SC, could serve as safe delivery systems for therapeutic agents across the blood-brain barrier, potentially aiding treatments in neurological disorders.
The cytotoxicity of single-walled carbon nanotubes (SWCNTs) suspended in various surfactants was investigated by phase contrast light microscopy characterization in combination with an absorbance spectroscopy cytotoxicity analysis. Our data indicate that individual SWCNTs suspended in the surfactants, sodium dodecyl sulfate (SDS) and sodium dodecylbenzene sulfonate (SDBS), were toxic to 1321N1 human astrocytoma cells due to the toxicity of SDS and SDBS on the nanotube surfaces. This toxicity was observed when cells were exposed to an SDS or SDBS solution having a concentration as low as 0.
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