Publications by authors named "Katherine K Loomba"
Article Synopsis
- - Chromosome instability (CIN) is common in tumors, often driven by the breakage-fusion-bridge (BFB) cycle, but detailed mechanisms are still unclear.
- - Researchers used a nuclease-dead Cas9 (dCas9) with a telomere-specific guide RNA to model the BFB cycle, finding that targeting telomeres causes DNA replication stress and increased DNA damage.
- - The study revealed significant chromosome end fusions and other structures related to chromosome bridges, highlighting multiple DNA repair pathways involved in tumorigenesis and drug resistance.
Chromosome instability (CIN) is frequently observed in many tumors. The breakage-fusion-bridge (BFB) cycle has been proposed to be one of the main drivers of CIN during tumorigenesis and tumor evolution. However, the detailed mechanisms for the individual steps of the BFB cycle warrants further investigation.
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