Publications by authors named "Katherine Jarrell"
Evaluation and description of a healthcare academia elective for student pharmacists.
Curr Pharm Teach Learn
February 2023
Article Synopsis
- The article discusses the introduction of an elective course aimed at exposing pharmacy students to academic roles and responsibilities.
- The course covered topics like curriculum design and assessment, culminating in students creating a continuing education presentation.
- Findings showed that students felt more confident in their academic knowledge and skills after completing the course, as measured by pre- and post-surveys.
Voclosporin: A Novel Calcineurin Inhibitor for the Treatment of Lupus Nephritis.
Ann Pharmacother
February 2022
Objective: To describe the safety, efficacy, and potential role in therapy of voclosporin, an oral calcineurin inhibitor approved by the Food and Drug Administration (FDA) in January 2021 as an adjunct treatment for lupus nephritis.
Data Sources: A literature search was conducted using PubMed with the following terms: voclosporin, Lupkynis, and lupus nephritis (January 1, 2010, to December 1, 2021). FDA product labeling was also reviewed for pertinent data sources.
Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert toxicity on cells of the central nervous system.
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- * Current treatments for breast cancer brain metastases (BCBM) include surgery, radiation, and chemotherapy, but they often don't significantly improve survival and are mainly palliative.
- * Recent advancements in chemotherapy have introduced new targeting agents and formulations, like PARP inhibitors and nanoparticles, which show promise and are being tested in ongoing clinical trials to improve treatment outcomes for BCBM.
Article Synopsis
- Canonical pre-mRNA splicing typically requires certain proteins (snRNPs) to remove long introns, but non-canonical splicing has been observed for some short introns in tRNAs and mRNAs, like XBP1.
- Researchers in this study developed a method to identify short introns using RNA-Seq data, finding hundreds of conserved short introns across different human cell types that are often alternatively spliced.
- The study reveals that splicing efficiency for these short introns can be enhanced by their secondary structures, and their removal can change the reading frame of mRNAs, indicating that current gene prediction models may not effectively account for these introns in the human transcriptome.