Publications by authors named "Katherine J Holzer"

Introduction: Oncologic surgeries are common and rates of depression and anxiety are high in the peri-operative period, potentially interfering with successful recovery.

Methods: We conducted a narrative review and meta-analysis focusing on randomised controlled trials evaluating the effect of peri-operative mental health interventions on anxiety and/or depression in adult patients having oncological surgery. The review included studies published in the last 5 years, identified through EMBASE with no pre-specified criteria for the type of comparison or outcome.

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Background: Postoperative anxiety and depression can negatively affect surgical outcomes and patient wellbeing. This study aimed to quantify the incidence of postoperative worsening anxiety and depression symptoms and to identify preoperative predictors of these conditions.

Methods: This prospective, observational cohort study included 1168 patients undergoing surgery lasting >1 h with overnight admission at a university-affiliated quaternary referral centre.

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Article Synopsis
  • - The perioperative period can cause significant anxiety and depression for patients due to fears about surgery and potential complications, highlighting the need for tailored psychological support during this time.
  • - A systematic review of 25 studies found that compassion-based interventions, focusing on improved communication and emotional support from healthcare professionals, reduced anxiety in 72% of cases and also showed positive impacts on patient satisfaction and postoperative outcomes.
  • - While the results are promising, the review noted limitations, such as unclear methods in many studies and a smaller number of studies suitable for deeper analysis, suggesting that more focused research is needed to solidify these findings in routine patient care.
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Objectives: Perioperative mental health of older Black surgical patients is associated with poor surgical outcomes; however, evidence-based perioperative interventions are lacking. Our two study objectives included: first, examine factors affecting perioperative care experiences of older Black surgical patients with mental health problems, and second, ascertain design and implementation requirements for a culturally-adapted perioperative mental health intervention.

Design Setting And Participants: We conducted six focus groups with older Black patients (n = 15; ≥50 years; surgery within the past 5 years and/or interest in mental health research; history of distress, anxiety, or depression coping with surgery/hospitalization/) from a large academic medical center.

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Preoperative depression is an underappreciated comorbidity that has important implications for postoperative outcomes. Screening for symptoms of depression before surgery can identify patients with or without a previous diagnosis of depression who could benefit from perioperative interventions to improve mood. Preoperative screening programmes are feasible to implement, although care must be taken to ensure that patients who are most likely to benefit are included.

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Introduction: Preoperative anxiety and depression symptoms among older surgical patients are associated with poor postoperative outcomes, yet evidence-based interventions for anxiety and depression have not been applied within this setting. We present a protocol for randomised controlled trials (RCTs) in three surgical cohorts: cardiac, oncological and orthopaedic, investigating whether a perioperative mental health intervention, with psychological and pharmacological components, reduces perioperative symptoms of depression and anxiety in older surgical patients.

Methods And Analysis: Adults ≥60 years undergoing cardiac, orthopaedic or oncological surgery will be enrolled in one of three-linked type 1 hybrid effectiveness/implementation RCTs that will be conducted in tandem with similar methods.

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Background: Older surgical patients with depression often experience poor postoperative outcomes. Poor outcomes may stem from brain-hazardous medications and subadequate antidepressant dosing.

Methods: This was a retrospective, observational cohort study covering the period between January 1, 2021 and December 31, 2021.

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Introduction: Previous studies suggest an association between cognitive flexibility and development of chronic pain after surgery. It is not known whether cognitive flexibility can be improved in patients with chronic pain.

Objectives: This study tested whether a neurocognitive training program results in improved cognitive flexibility and pain in patients with chronic pain.

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Article Synopsis
  • - Recent shifts in clinical research recognize patients as valuable contributors beyond just participants, highlighting their importance in every phase of the research process.
  • - Engaging patients from the outset leads to research that is more relevant and practical for those affected by specific conditions, with increased support from research funders and regulatory bodies.
  • - A meeting organized by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials sought to create guidelines for better patient engagement in clinical pain research, focusing on aspects like representation, timing, and effective communication.
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Article Synopsis
  • Anxiety and depression are prevalent in older adults, particularly around surgery, but existing mental health interventions often overlook their specific needs; thus, a new perioperative mental health (PMH) bundle was developed, focusing on behavioral activation and medication optimization.
  • The research involved a combination of workshops, interviews, and audio recordings from various stakeholders to refine the PMH bundle, using multiple analytical methods to assess adaptations made based on patient and caregiver feedback.
  • Key findings revealed that nearly half of the adaptations focused on intervention content tailored to patient preferences, with the importance of compassion highlighted as a vital element, demonstrating the need for personalized approaches in mental health interventions for older surgical patients.
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Objectives: The perioperative period is challenging and stressful for older adults. Those with depression and/or anxiety have an increased risk of adverse surgical outcomes. We assessed the feasibility of a perioperative mental health intervention composed of medication optimization and a wellness program following principles of behavioral activation and care coordination for older surgical patients.

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Background: There is a well-established relationship between high allostatic load (AL) and increased risk of mortality. This study expands on the literature by combined latent profile analysis (LPA) with survival data analysis techniques to assess the degree to which AL status is associated with time to death.

Methods: LPA was employed to identify underlying classes of biological dysregulation among a sample of 815 participants from the Midlife in the US study.

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Introduction: People who experience human trafficking (HT) visit emergency departments (ED). The International Classification of Diseases, Clinical Modification (ICD-10-CM) introduced codes to document HT in June 2018. The aim of this study is to identify characteristics of ED patients who experienced forced labor or sexual exploitation as a documented external cause of morbidity in US visits.

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For individuals experiencing pain, the decision to engage in clinical trials may be influenced by a number of factors including current and past care, illness severity, physical functioning, financial stress, and caregiver support. Co-occurring depression and anxiety may add to these challenges. The aim of this scoping review was to describe perspectives about clinical trial participation, including recruitment and retention among individuals with pain and pain comorbidities, including depression and/or anxiety.

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Introduction: The perioperative period is high risk for older adults. Depression and anxiety are common perioperative problems, frequently coexisting with cognitive impairment. Older patients with these conditions are more likely than younger patients to experience postoperative delirium, long hospital stays, poor quality of life and rehospitalisation.

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Little is known-especially with regard to gender differences-about the prescription trends among justice-involved individuals with health conditions after release from correctional facilities. This article presents initial findings from a large outreach program designed to provide prescription support during the turbulent prison-to-community transition period. We analyzed data derived from a prescription outreach program during the years 2018-2019.

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Article Synopsis
  • There is a growing interest in involving patients as partners in clinical trials for pain treatments, but there is currently no specific guidance on how to do this effectively.
  • This review discusses historical and current perspectives on patient engagement in clinical research, including how regulatory and funding agencies are beginning to incorporate patient input in their decision-making.
  • The authors highlight key practices for recruiting and engaging patients, the benefits and challenges of these partnerships, and outline factors that impact patient engagement in pain-related studies, as well as gaps for future research to improve patient-centered clinical research.
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Background: The rapid spread of the coronavirus disease 2019 (COVID-19) has created considerable strain on the physical and mental health of healthcare workers around the world. The effects have been acute for physician trainees-a unique group functioning simultaneously as learners and care providers with limited autonomy.

Objective: To investigate the longitudinal effects of physician trainee exposure to patients being tested for COVID-19 on stress, anxiety, depression, and burnout using three surveys conducted during the early phase of the pandemic.

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Background: Persistent postsurgical pain (PPSP) is a common complication that impacts quality of life, often necessitating long-term opioid treatment. Certain neurocognitive factors, including reduced performance on cognitive flexibility tasks, are associated with increased risk of PPSP. We examine the perceptions of surgical patients and clinicians with regard to perioperative pain management activities and needs; patient acceptance and use of a perioperative neurocognitive training intervention; and implementation feasibility.

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Article Synopsis
  • Clinical decision support systems and telemedicine can enhance surgical care, yet there's a gap in understanding patient perspectives on electronic operating rooms (eOR) for remote monitoring.
  • The study aimed to assess patients' attitudes towards eOR monitoring and identify barriers and facilitators to its use.
  • Results indicated that participants felt more comfortable with familiar clinicians monitoring their health during surgery compared to unfamiliar ones, emphasizing the importance of trust in patient care.
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Objectives: This article investigates the association between changes in electronic health record (EHR) use during the coronavirus disease 2019 (COVID-19) pandemic on the rate of burnout, stress, posttraumatic stress disorder (PTSD), depression, and anxiety among physician trainees (residents and fellows).

Methods: A total of 222 (of 1,375, 16.2%) physician trainees from an academic medical center responded to a Web-based survey.

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Article Synopsis
  • Sexual assault is a serious public health issue in the U.S., leading to lasting effects on victims, and accurate medical documentation is crucial for legal outcomes.
  • The study analyzes factors influencing how emergency department visits for sexual assault are coded, using data from the 2016 Nationwide Emergency Department Sample.
  • Factors like younger age, being female, more medical procedures, hospital location in urban areas, and no alcohol use at the time of the assault are linked to coding cases as confirmed sexual assault.
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The prevalence of antisocial personality disorder (ASPD) decreases with age. As such, research regarding ASPD typically focuses on children and younger adults. The apparent age-specific prevalence of ASPD may be due, in part, to diagnostic criteria informed by research excluding older adults.

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