Pembrolizumab plus chemotherapy for first-line treatment of advanced triple-negative breast cancer.

A systematic review and network meta-analysis (NMA) was performed to evaluate the efficacy of first-line treatments for locally recurrent unresectable or metastatic triple-negative breast cancer (TNBC) patients. Databases were searched for randomized controlled trials evaluating first-line treatments for locally recurrent unresectable or metastatic TNBC patients. NMA was performed to estimate relative treatment effects on overall and progression-free survival between pembrolizumab + chemotherapy and other interventions.

Clinical outcomes for previously treated patients with advanced biliary tract cancer: a meta-analysis.

A systematic review and meta-analysis were performed to evaluate the efficacy of treatments for previously treated advanced biliary tract cancer (BTC) patients. Databases were searched for studies evaluating treatments for advanced (unresectable and/or metastatic) BTC patients who progressed on prior therapy. Pooled estimates of objective response rate (ORR), median overall survival (OS) and median progression-free survival (PFS) were calculated using random effects meta-analysis.

Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life.

Purpose: Chronic cough (CC), defined as a cough persisting ≥ 8 weeks, can have a substantial negative impact on health-related quality of life (HRQoL). This is exacerbated by challenges with timely diagnosis and a lack of approved therapies. A systematic literature review (SLR) was conducted to identify evidence on HRQoL and health state utility values associated with refractory CC or unexplained CC.

Clinical Outcomes of PD-1/PD-L1 Inhibitors Among Patients With Advanced or Metastatic Non-Small Cell Lung Cancer With BRAF, ERBB2/HER2, MET , or RET Alterations: A Systematic Literature Review.

The therapeutic landscape for patients with advanced or metastatic non-small cell lung cancer (NSCLC) is rapidly evolving due to advances in molecular testing and the development of new targeted therapies and immunotherapies. However, the efficacy of programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in advanced or metastatic patients with NSCLC whose tumors harbor BRAF V600E mutation, HER2/ERBB2 alteration, MET exon 14 skipping mutation, or RET rearrangement is not completely understood. A systematic literature review was performed to summarize evidence from clinical trials and observational studies on objective response rate, progression-free survival, and overall survival in patients whose tumors express these biomarkers and who were treated with PD-1/PD-L1 inhibitors.

Understanding the economic burden of chronic cough: a systematic literature review.

Chronic cough (CC) is associated with high healthcare resource utilization (HCRU) due to challenges in diagnosis and treatment and is anticipated to have a substantial economic impact. This systematic literature review (SLR) sought to identify evidence on the cost-effectiveness of treatments and the economic burden associated with CC. Electronic database searches were supplemented with searches of conference proceedings and health technology assessment body websites.

Approaches and geographical locations of respectful maternity care research: A scoping review.

Background: Peripartum mistreatment of women contributes to maternal mortality across the globe and disproportionately affects vulnerable populations. While traditionally recognized in low/low-middle-income countries, the extent of research on respectful maternity care and the types of mistreatment occurring in high-income countries is not well understood. We conducted a scoping review to 1) map existing respectful maternity care research by location, country income level, and approach, 2) determine if high-income countries have been studied equally when compared to low/low-middle-income countries, and 3) analyze the types of disrespectful care found in high-income countries.

Neoadjuvant immunotherapy and chemotherapy regimens for the treatment of high-risk, early-stage triple-negative breast cancer: a systematic review and network meta-analysis.

Background: Patients with triple-negative breast cancer (TNBC) are generally younger and more likely to experience disease recurrence and have the shortest survival among all breast cancer patients. Recently, neoadjuvant delivery of the programmed cell death protein-1 inhibitor pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab was approved for patients with high-risk, early-stage TNBC, but this treatment regimen has not been evaluated in head-to-head trials with other neoadjuvant treatment regimens. Therefore, the objective of this study was to estimate the relative efficacy of neoadjuvant pembrolizumab + chemotherapy followed by adjuvant pembrolizumab versus other neoadjuvant treatments for early-stage TNBC through a systematic review and network meta-analysis (NMA).

Domains of professional practice: analysis of publications in the Journal of the Medical Library Association from 2010 to 2019.

The Medical Library Association (MLA) has defined 7 domain hubs aligning to different areas of information professional practice. To assess the extent to which content in the () is reflective of these domains, we analyzed the magnitude of JMLA articles aligning to each domain hub over the last 10 years. Bibliographic records for 453 articles published in from 2010 to 2019 were downloaded from Web of Science and screened using Covidence software.

Efficacy analysis of different FLT3 inhibitors in patients with relapsed/refractory acute myeloid leukemia and high-risk myelodysplastic syndrome.

Several FLT3 inhibitors(i) are available to treat relapsed/refractory (R/R) -internal tandem duplicated acute myeloid leukemia (AML). This study analyzes the efficacies of various FLT3i (types 1 and 2) tested in clinical trials in treating R/R AML and high-risk myelodysplastic syndromes (HR-MDS). PubMed and EMBASE databases were searched for single/double-arm phase I/II/III R/R AML or HR-MDS clinical trials published between 1/1/2000 and 6/1/2021.

Timing of embolic phenomena after hydrogen peroxide exposure - a systematic review.

Introduction: Hydrogen peroxide ingestions cause significant morbidity and mortality due to oxygen gas emboli and are treatable with hyperbaric oxygen therapy. Recommendations for observation are based on small case series.

Objectives: The aim of this systematic review is to define the time of onset of embolic phenomena after hydrogen peroxide exposure and to describe the proportion of patients who received hyperbaric oxygen therapy.

Treatment of Self-Harm Scars: A Scoping Review.

Background: Self-harm scars are a consequence of deliberate self-injury, serving as a visual reminder for involved individuals. Patients often reach out to their providers seeking treatment for their scars. However, there is currently no standard for treating self-harm scars, because multiple options are being explored.

Insights and opinions of readers of the .

The conducted a readership survey in 2020 to gain a deeper understanding of our readers, their reading habits, and their satisfaction with 's content, website functionality, and overall quality. A total of 467 readers responded to the survey, most of whom were librarians/information specialists (85%), worked in an academic (62%) or hospital/health care system (27%) library, and were current Medical Library Association members (80%). Most survey respondents (46%) reported reading articles on a quarterly basis.

Building First-Year Medical Students' Skills in Finding, Evaluating, and Visualizing Health Information Through a "Debunking Medical Myths" Curricular Module.

Unlabelled: To provide an online service learning opportunity for medical students during the COVID-19 pandemic, medical faculty and librarians developed and implemented a "Debunking Medical Myths" module in which students learned to search for emerging medical literature, evaluate evidence, and use that evidence to create an infographics debunking a COVID-19-related myth for a non-medical audience. The resultant infographics are visually appealing and designed to make complex health information easy to understand. The module was well-received by students, who demonstrated a nuanced understanding of the use of infographics to convey health information, and students' work was evaluated highly by community members.

Creating a more inclusive journal: the 's evolving process for selecting editorial board members.

The selects new editorial board members every year. In the spring of 2021, used a new process for reviewing and selecting applicants for the limited number of open editorial board positions. This reevaluation of the selection process was spurred by a desire to create a more diverse and representative board.

Updating the landmark literature for the practice of geriatrics: Notable articles from 2012-2019.

Background: Remaining current on the latest advances in the peer-reviewed literature is a basic tenant of medical education and evidence-based practice. We updated an important prior publication (Vaughan, et al.) identifying landmark articles in geriatric medicine by considering the influence of altmetrics and updating the list with notable articles published between 2012 and 2019.

Air quality monitoring and measurement in an urban airshed: Contextualizing datasets from the Detroit Michigan area from 1952 to 2020.

With urban air quality being a pressing public health concern, community members are becoming increasingly engaged in determining the links between air quality and human health. Although new measurement tools such as low-cost sensors make local data more accessible, a better understanding of gaps in regional datasets is needed to develop effective metropolitan-scale solutions. Using scoping review methodology, we compiled 214 published journal articles and grey literature reports of air quality data from the Detroit, Michigan area from 1952 through 2020.

Bicycle handlebar injuries - a systematic review of pediatric chest and abdominal injuries.

Objective: The severity of handlebar injuries can be overlooked due to subtle signs and wide range of associated internal injuries. Our objective was to describe thoracoabdominal injuries due to bicycle handlebars and their outcomes in children.

Methods: Articles that reported thoracoabdominal injuries were identified from database conception to March 3, 2019 using PubMed, EMBASE, Cochrane Library, CINHAHL Complete, Web of Science and Scopus.

CRediT for authors of articles published in the .

To help ensure that authors of articles published in the () receive appropriate recognition for their contributions and to make individual author roles more transparent to readers, articles will begin including Author Contribution statements using the Contributor Role Taxonomy.

Striving for equity: An update from the .

In 2020, the () launched an initiative aimed at providing more equitable opportunities for authors, reviewers, and editorial team members. This editorial provides an update on the steps we have taken thus far to empower authors, increase the diversity of our editorial team, and make equity-minded recommendations to the Medical Library Association.

Racial, gender, sexual, and disability identities of the 's editorial board, reviewers, and authors.

The recently issued a call for submissions that recognize and address social injustices; speak to diversity, equity, and inclusion in our workforce and among our user populations; and share critical perspectives on health sciences librarianship as well as those on any topic within 's scope written by authors who are Black, Indigenous, or People of Color. We also committed to creating more equitable opportunities for authors, reviewers, and editorial board members from marginalized groups. As part of this effort, we conducted a demographic survey of all individuals who served as a member of the editorial board or reviewer or had submitted a manuscript to between 2018 and 2020.

The state of the journal: the in 2020.

As the premier journal in health sciences librarianship, the () continuously strives to publish high-quality work that advances research and practice and to provide irreplaceable value for readers, authors, and reviewers. This editorial reflects on the state of in 2020 by describing our editorial team and volume of submissions, highlighting recent initiatives that strengthen the journal's position in the profession, and sharing future plans to enrich 's content and promote open science. Committed to ending structural racism and other inequities in the field, we also issue an ongoing call for submissions pertaining to social justice and critical perspectives on health sciences librarianship.

Clinical and procedural implications of congenital vena cava anomalies in adults: A systematic review.

Background: Although congenital vena cava (CVC) anomalies in adults have implications for surgical and radiological interventions, the literature is scare and disparate. The aim of this systematic review was to assess cardiovascular clinical and procedural implications of CVC anomalies in adults without congenital heart disease.

Methods And Results: We searched PubMed and EMBASE from database conception through October 2018 for English-language studies describing the epidemiology of CVC anomalies or their clinical or procedural implications in humans.

Report from the Medical Library Association's InSight Initiative Summit 3: Bridge Building: What Bridges to Build and How.

At the Medical Library Association's Insight Initiative Summit 3, held June 12-13, 2019, academic and hospital librarians joined with publishing industry partners to identify vexing problems in publishing and accessing health sciences information. Through a mixture of panel discussions with health sciences faculty, librarians, and information providers; small-group problem-solving exercises; and large-group consensus-building activities, the summit program invited participants to appreciate each other's viewpoints and propose a collaborative project leading to tangible outcomes that could ultimately benefit end users. Several vexing problems were identified, including poor communication and mistrust between librarians and publishers, complexities in product pricing structures and licenses, and users' difficulties in accessing and using vetted information resources.

Resuscitation Guided by Volume Responsiveness Does Not Reduce Mortality in Sepsis: A Meta-Analysis.

Unlabelled: Resuscitation with IV fluids is a critical component in the management of sepsis. Although the optimal volume of IV fluid is unknown, there is evidence that excessive administration can be deleterious. Static measures of volume status have not proven to be meaningful resuscitative endpoints.

Sharing your work by self-archiving: encouragement from the .

Self-archiving offers opportunities for authors to more broadly disseminate their work-both in pre-print form before its submission to a journal and in post-print form after its acceptance and publication in a journal. This editorial provides authors with guidance in navigating the rapidly changing options for self-archiving and affirms that the encourages authors to self-archive their work to boost its reach and impact.