Publications by authors named "Katherine E Stephenson"
Background: Epithelial damage, repair and remodelling are critical features of chronic airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged airway epithelia causes inflammation its receptor, serum stimulation-2 (ST2). Oxidation of IL-33 to a non-ST2-binding form (IL-33) is thought to limit its activity.
View Article and Find Full Text PDFBackground: Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with limited treatment options. Interleukin-33 (IL-33) is proposed to play a role in the development of IPF however the exclusive use of prophylactic dosing regimens means that the therapeutic benefit of targeting this cytokine in IPF is unclear.
Methods: IL-33 expression was assessed in ILD lung sections and human lung fibroblasts (HLFs) by immunohistochemistry and gene/protein expression and responses of HLFs to IL-33 stimulation measured by qPCR.
Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis.
Am J Physiol Lung Cell Mol Physiol
March 2023
Article Synopsis
- In people with chronic asthma, the airways in their lungs change over time, like getting thicker and having more stuff in them.
- Scientists studied this in mice and discovered that the way the airways change is different depending on their size.
- A new method helped them see these differences better, showing that some changes go away quickly while others stick around longer, which might affect asthma symptoms in the long run.