Sex differences in associations between psychosocial factors and aberrant crypt foci among patients at risk for colon cancer.

Background: Psychosocial factors may impact cancer risk but sex differences in this domain are understudied. Examining psychosocial factors, such as depression and social support, among colon cancer patients allows for a unique opportunity to study sex differences in the association between psychosocial factors and colon cancer risk in this population.

Objective: The primary aim of this study was to evaluate sex differences in the association between key psychosocial factors and aberrant crypt foci (ACF), a putative biomarker of colon cancer risk.