Zebrafish Deficiency Impairs Retinal Patterning and Oculomotor Function.

Down syndrome cell adhesion molecules ( and ) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit function are still mostly unexplored. We investigated the functional consequences of deficiency in the larval zebrafish (sexually undifferentiated) oculomotor system, where behavior, circuit function, and neuronal activity can be precisely quantified. Genetic perturbation of resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in mammals.