Publications by authors named "Katherine E Cullen"
Background: The best treatment options for binge-eating disorder are unclear.
Purpose: To summarize evidence about the benefits and harms of psychological and pharmacologic therapies for adults with binge-eating disorder.
Data Sources: English-language publications in EMBASE, the Cochrane Library, Academic OneFile, CINAHL, and ClinicalTrials.
Article Synopsis
- HSF1 binds to HSP gene promoters to boost their transcription in response to stress, crucial for cell survival.
- The interaction between HSF1 and symplekin, observed after stress, helps in the processing of Hsp70 mRNA, enhancing its polyadenylation.
- Disrupting the HSF1-symplekin complex hampers Hsp70 production, leading to reduced protein induction and higher cell death under stress conditions.