Publications by authors named "Katherine Dewey"
Background: Invasive fungal infections can cause serious complications after lung transplant; therefore, prophylaxis with posaconazole is common. The posaconazole delayed-release (DR) tablet is preferred. Although the package insert states DR tablets cannot be crushed, recent data suggest it is reasonable.
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- Fractures significantly reduce quality of life and survival rates, and this study aimed to predict fracture risk post-lung transplant based on frailty scores and genetic profiles of recipients.
- In a study of 284 lung transplant recipients, high rates of osteoporosis and fractures were observed, with 59% experiencing osteopenia and 35% sustaining at least one fracture post-transplant.
- The findings indicated that lower bone mineral density was linked to genetic risk factors for osteoporosis, and pretransplant frailty was associated with an increased risk of specific fractures, highlighting the need for monitoring and prevention strategies for osteoporosis after lung transplant.
Background: Limited data and guidelines exist for using nirmatrelvir/ritonavir in solid organ transplant recipients stabilized on tacrolimus for the treatment of mild-to-moderate coronavirus disease. Concern exists regarding the impact of utilizing a 5-d course of nirmatrelvir/ritonavir with calcineurin inhibitors because of significant drug-drug interactions between ritonavir, a potent cytochrome P450 3A inhibitor, and other cytochrome P450 3A substrates, such as tacrolimus.
Methods: We report the successful use of nirmatrelvir/ritonavir in 12 outpatient lung transplant recipients with confirmed severe acute respiratory syndrome coronavirus 2 infection stabilized on tacrolimus immunosuppression.
Most lung transplantation immunosuppression regimens include tacrolimus. Single nucleotide polymorphisms (SNPs) in genes important to tacrolimus bioavailability and clearance (ABCB1, CYP3A4, and CYP3A5) are associated with differences in tacrolimus pharmacokinetics. We hypothesized that polymorphisms in these genes would impact immunosuppression-related outcomes.
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