Publications by authors named "Katherine D Lach"
Article Synopsis
- - Obesity can cause inflammation in the body and make cancer spread faster, especially breast cancer spreading to the lungs.
- - Researchers discovered that certain immune cells called monocytes work with other immune cells called neutrophils to help breast cancer spread in people who are obese.
- - They found that these monocytes change and become more active when someone is obese, which helps in the cancer spreading process.
Metastasis is the leading cause of cancer-related deaths, and obesity is associated with increased breast cancer (BC) metastasis. Preclinical studies have shown that obese adipose tissue induces lung neutrophilia associated with enhanced BC metastasis to this site. Here we show that obesity leads to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung.
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