Publications by authors named "Katherine Cobb-Pitstick"
Article Synopsis
- Mutations in the NPRL3 gene, linked to epilepsy and brain development issues, were studied in a Mennonite community, revealing a 28% rate of epilepsy with diverse clinical symptoms.* -
- Researchers used CRISPR/Cas9 to knock out Nprl3 in mouse brain cells, finding that its absence leads to excessive mTOR pathway activation and abnormal cell behavior, which can be mitigated by mTOR inhibitors.* -
- No specific genetic modifiers were identified that could explain the variability in seizure occurrence among the subjects, indicating that NPRL3 plays a significant role in mTOR signaling and potential epilepsy mechanisms.*
Objective: To evaluate factors that influence migraine recurrence after outpatient infusion or inpatient treatment for intractable migraine.
Background: Recurrence of migraine after acute treatment in an infusion center or an inpatient setting is not well documented in children and adolescents. Given the multifactorial pathogenesis of migraines, multiple factors may influence migraine recurrence.