Publications by authors named "Katherine C Du"
Checkpoint inhibitors (CPIs) targeting programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) have revolutionized cancer treatment but can trigger autoimmune complications, including CPI-induced diabetes mellitus (CPI-DM), which occurs preferentially with PD-1 blockade. We found evidence of pancreatic inflammation in patients with CPI-DM with shrinkage of pancreases, increased pancreatic enzymes, and in a case from a patient who died with CPI-DM, peri-islet lymphocytic infiltration. In the NOD mouse model, anti-PD-L1 but not anti-CTLA-4 induced diabetes rapidly.
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- - More than one billion people live with disabilities globally, facing significant discrimination and health disparities, especially in developing nations where 80% of this population resides, hindering their access to sexual and reproductive health (SRH) services.
- - A study in Bangladesh used a mixed-methods approach to investigate how education influences the utilization of SRH services among persons with disabilities, surveying 5,000 individuals and conducting 15 in-depth case studies.
- - The results indicate that higher education levels correlate with increased use of SRH services, while those with lower educational attainment reported misinformation and negative experiences with healthcare providers, leading to a decline in service-seeking behavior.