Ly6c non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

Perinatal hepatic inflammation can have devastating consequences. Monocytes play an important role in the initiation and resolution of inflammation, and their diverse functions can be attributed to specific cellular subsets: pro-inflammatory or classical monocytes (Ly6c) and pro-reparative or non-classical monocytes (Ly6c). We hypothesized that inherent differences in Ly6c classical monocytes and Ly6c non-classical monocytes determine susceptibility to perinatal hepatic inflammation in late gestation fetuses and neonates.