Publications by authors named "Katherine A Kaiser"
Article Synopsis
- Regulatory T (Treg) cells are important for tissue repair by providing growth factors like amphiregulin (Areg), but studying Areg-producing Treg cells has been challenging due to isolation difficulties.
- The researchers developed a new reporter mouse that allows detection of Areg expression in live cells and used it to analyze Treg cells in lung damage models, revealing distinct subpopulations.
- Their analysis showed that Areg-producing Treg cells are favored during damage, with functional differences highlighted, and they identified a novel mechanism, 4-1BB agonism, that promotes tissue repair activity.
Micronutrient deficiency is a major cause of disease throughout the world. Yet, how perturbations influence the immune-microbiome interface remains poorly understood. Here, we report that loss of dietary tryptophan (Trp) reshapes intestinal microbial communities, including the depletion of probiotic L.
View Article and Find Full Text PDFFollowing respiratory viral infection, regeneration of the epithelial barrier is required to preserve lung function and prevent secondary infections. Lung regulatory T (Treg) cells are critical for maintaining blood oxygenation following influenza virus infection through production of the EGFR ligand amphiregulin (Areg); however, how Treg cells engage with progenitors within the alveolar niche is unknown. Here, we describe local interactions between Treg cells and an Areg-responsive population of Col14a1+EGFR+ lung mesenchymal cells that mediate type II alveolar epithelial (AT2) cell-mediated regeneration following influenza virus infection.
View Article and Find Full Text PDFThe gut commensal bacterium promotes immune tolerance by facilitating the induction of colonic regulatory T cells.
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