Toxic clozapine level as first indication of severe, acute infection.

Background: Clozapine levels can be influenced by many factors, including pharmacogenomic variability, pharmacokinetic drug interactions, and infection/inflammation. The concentration-to-dose ratio (C/D), a measure of a medication's rate of metabolism and clearance, may increase during an acute infection due to decreased medication metabolism and clearance.

Case Report: A 56-year-old White man was restarted on clozapine and titrated up to 350 mg/d with therapeutic steady-state levels (C/D 1.

Antibiotic utilization variability among training services at an academic medical center: An observational study.

Objective: Evaluate the difference in antibiotic prescribing between various levels of resident training or attending types.

Design: Observational, retrospective study.

Setting: Tertiary-care, academic medical center in Madison, Wisconsin.