Publications by authors named "Katharine Williams"

Examination of avian eggshell at the Old Town archaeological site in Southwestern New Mexico, United States of America, indicates that scarlet macaw () breeding occurred during the Classic Mimbres period (early AD 1100s). Current archaeological and archaeogenomic evidence from throughout the American Southwest/Mexican Northwest (SW/NW) suggests that Indigenous people bred scarlet macaws at an unknown location(s) between AD 900 and 1200 and likely again at the northwestern Mexico site of Paquimé post-AD 1275. However, there is a lack of direct evidence for breeding, or the location(s) of scarlet macaw breeding itself, within this area.

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Lipid oxidation and biosynthesis are crucial for cell survival, especially for rapidly proliferating cancer cells in a heterogeneous metabolic environment. The storage of high-energy lipid reservoirs competitively advantages the cancer cell over non-neoplastic tissue. Disrupting lipid biosynthetic processes, through modulation of fatty acid (FA) esterification or lipogenesis (DNL), is of interest in drug discovery.

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Context: A high relapse rate after discontinuation of desmopressin treatment of pediatric enuresis is consistently reported. Structured withdrawal strategies have been used to prevent relapse.

Objective: To assess the efficacy of a structured withdrawal strategy of desmopressin on the relapse-free rate for desmopressin responder pediatric enuresis.

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Objective: This study examined the relationship between hearing impairment and mental distress. We hypothesized that fear of negative evaluation by others and avoidant communication strategies are associated with increased symptoms of depression.

Method: Hearing-impaired adults (N = 105) who signed up for a stress management course completed the Hospital Anxiety and Depression Scale (HAD; Zigmond & Snaith, 1983), the Fear of Negative Evaluation Scale (FNE; Watson & Friend, 1969), and the Conversation Tactics Checklist (CONV; Hallam et al.

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Objective: To develop a cognitive therapy program to reduce mental distress among hearing-impaired employees.

Design: In a pilot study we measured the development of mental distress and avoidant coping among hearing-impaired employees. Levels of mental distress were assessed using the hospital anxiety and depression scale (HAD), and the extent of avoidance with conversation tactics checklist CONV(AVOID).

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Objective: Oxybutynin is the current gold standard drug for management of overactive bladder (OAB) in children, but can have significant side effects or be difficult to administer in multiple daily doses. Herein, we report our experience with transdermal oxybutynin patch (TOP) as an alternative in a selected patient population without neuropathic compromise.

Materials And Methods: Consecutive patients assessed in a pediatric urology clinic over a 1-year period, diagnosed with OAB with minimum follow-up of 3 months, were included.

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Article Synopsis
  • A synthetic method using (-)-quinic acid was developed to create analogues of the natural product antheminone A.
  • A crucial step in the synthesis involved conjugate addition, which had unpredictable stereochemical results, ultimately leading to two series of diastereoisomeric compounds.
  • The synthesized compounds were tested for toxicity against the A549 non-small-cell lung cancer cell line, and the results of these assays are discussed.
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During the studies towards the development of pentafluorophenyldimethylsilanes as a novel organosilicon cross coupling reagent it was revealed that the active silanolate and the corresponding disiloxane formed rapidly under basic conditions. The discovery that disiloxanes are in equilibrium with the silanolate led to the use of disiloxanes as cross coupling partners under fluoride free conditions. Our previous report focused on the synthesis and base induced cross coupling of aryl substituted vinyldisiloxanes with aryl halides; good yields and selectivities were achieved.

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