Publications by authors named "Katharine R Price"
The Number of Radiographically Positive Lymph Nodes Further Stratifies Patient Survival Among Clinical N1 Patients With Human Papillomavirus-Associated Oropharyngeal Cancer.
Roman O Kowalchuk Kathryn M Van Abel Adam B Sauer Linda X Yin Joaquin J Garcia Daniel L Price Katharine R Price
Adv Radiat Oncol
February 2022
Article Synopsis
- HPV-associated oropharyngeal squamous cell carcinoma (HPV[+]OPSCC) needs refined clinical staging to enhance treatment decisions, specifically by analyzing the number of radiographically positive lymph nodes in patients classified as clinical N1 (cN1).
- A study involving 260 patients who underwent surgical treatment and various radiation therapies found that the count of positive lymph nodes significantly influenced progression-free survival (PFS), with higher counts correlating to worse outcomes.
- The findings suggest using the number of positive lymph nodes as a meaningful categorization tool for cN1 patients with HPV(+)OPSCC, warranting further research to validate these results.
Article Synopsis
- The study investigates the effectiveness of CT and PET/CT scans in detecting involvement of more than 4 lymph nodes (rN2) and extranodal extension (rENE) in patients with HPV-positive oropharyngeal cancer.
- Results showed CT had a sensitivity of 59% and specificity of 92% for detecting more than 4 lymph nodes, while both imaging techniques performed similarly overall.
- Patients with fewer than 4 involved lymph nodes (rN0-1) had a high likelihood of being classified as pN0-1, indicating that rN0-1 status can help guide treatment decisions and clinical trial participation.
Objective: To describe and compare rates of metachronous and synchronous second primaries of the contralateral tonsil in patients with primary HPV(+) tonsillar squamous cell carcinoma (SCC).
Study Design: Retrospective cohort study.
Materials And Methods: This is a single tertiary care center retrospective case series, from 2006 to 2019, of HPV(+) tonsillar SCC patients who underwent primary surgical resection with unilateral wide-field tonsillectomy or bilateral tonsillectomy for diagnostic or therapeutic purposes.