glycan biosynthesis modulates host immune cell recognition and response.

Introduction: The pathogenic bacterium has evolved glycan-mediated mechanisms to evade host immune defenses. This study tests the hypothesis that genetic disruption of glycan biosynthesis alters immune recognition and response by human gastric epithelial cells and monocyte-derived dendritic cells.

Methods: To test this hypothesis, human cell lines were challenged with wildtype alongside an array of glycosylation mutants.