Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function.

The auditory mismatch negativity (MMN) has been proposed as a biomarker of NMDA receptor (NMDAR) dysfunction in schizophrenia. Such dysfunction may be caused by aberrant interactions of different neuromodulators with NMDARs, which could explain clinical heterogeneity among patients. In two studies (N = 81 each), we used a double-blind placebo-controlled between-subject design to systematically test whether auditory mismatch responses under varying levels of environmental stability are sensitive to diminishing and enhancing cholinergic vs.

Hierarchical Bayesian models of social inference for probing persecutory delusional ideation.

While persecutory delusions (PDs) have been linked to fallacies of reasoning and social inference, computational characterizations of delusional tendencies are rare. Here, we examined 151 individuals from the general population on opposite ends of the PD spectrum (Paranoia Checklist [PCL]). Participants made trial-wise predictions in a probabilistic lottery, guided by advice from a more informed human and a nonsocial cue.

Inflexible social inference in individuals with subclinical persecutory delusional tendencies.

It has been suspected that abnormalities in social inference (e.g., learning others' intentions) play a key role in the formation of persecutory delusions (PD).

Focus of attention modulates the heartbeat evoked potential.

Theoretical frameworks such as predictive coding suggest that the perception of the body and world - interoception and exteroception - involve intertwined processes of inference, learning, and prediction. In this framework, attention is thought to gate the influence of sensory information on perception. In contrast to exteroception, there is limited evidence for purely attentional effects on interoception.