Publications by authors named "Katharina Stopfer"
Article Synopsis
- The LiverRisk score is a proposed blood test aimed at estimating liver stiffness and identifying patients at risk for compensated advanced chronic liver disease (cACLD) and liver-related events without prior known liver issues.
- In a study involving nearly 7,500 patients, the score's diagnostic performance was evaluated against established methods like FIB-4 and APRI, revealing that while it moderately correlates with liver stiffness measurements, it tends to underestimate them.
- Although the LiverRisk score demonstrated decent accuracy for predicting cACLD and hepatic decompensation, its limitations include a low negative predictive value, indicating it might not effectively rule out disease in some patients.
Article Synopsis
- The study aimed to create a blood-based algorithm using FIB-4 and VITRO to identify compensated advanced chronic liver disease (cACLD) and clinically significant portal hypertension (CSPH) in patients, especially in settings without access to liver stiffness measurements.
- A total of 6,143 patients were analyzed; results showed that both LSM and FIB-4 were effective in predicting hepatic decompensation, with a notable risk difference based on FIB-4 levels (≥ 1.75 significantly increasing risk).
- In a separate cohort, VITRO demonstrated strong diagnostic performance for CSPH, comparable to other established methods, suggesting a reliable means to identify patients at risk for liver-related complications.
Background & Aims: Liver stiffness measurements (LSMs) provide an opportunity to monitor liver disease progression and regression noninvasively. We aimed to determine the prognostic relevance of LSM dynamics over time for liver-related events and death in patients with chronic liver disease.
Methods: Patients with chronic liver disease undergoing 2 or more reliable LSMs at least 180 days apart were included in this retrospective cohort study and stratified at baseline (BL) as nonadvanced chronic liver disease (non-ACLD, BL-LSM < 10 kPa), compensated ACLD (cACLD; BL-LSM ≥ 10 kPa), and decompensated ACLD.
Threat sensitivity is a prominent predictor of interpersonal dysfunctions in borderline personality disorder (BPD), leading to intense, aversive feelings of threat and eventually dysfunctional behaviors, such as aggression. In the present study, BPD patients and healthy volunteers classified angry, fearful, neutral, and happy faces presented for 150 ms or 5,000 ms to investigate initial saccades and facial scanning. Patients more often wrongly identified anger, responded slower to all faces, and made faster saccades towards the eyes of briefly presented neutral faces and slower saccades away from fearful eyes compared with healthy volunteers.
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