Publications by authors named "Katharina Sorg"

Significance: Optoacoustic stimulation offers an alternative stimulation strategy for the hearing organ. To serve as the base for a novel auditory prosthesis, the optoacoustic stimulation must be biocompatible and energy-saving.

Aim: Enhancing the efficiency of optoacoustic stimulation while reducing the energy input in a suited animal model.

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Significance: Optoacoustic-induced vibrations of the hearing organ can potentially be used for a hearing device. To increase the efficiency of such a hearing device, the conversion of the light energy into vibration energy within each type of irradiated tissue has to be optimized.

Aim: To analyze the wavelength-dependency of optoacoustic-induced vibrations within the tympanic membrane (TM), and to define the most efficient and best-suited optical stimulation parameters for a novel auditory prosthesis.

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Article Synopsis
  • About 460 million people around the world have trouble hearing, and many can't get the help they need from current hearing aids.
  • Scientists are trying out a new way to help with hearing using laser light to stimulate the ear, which could be better than what we have now.
  • They tested how safe this laser treatment is on certain human cells, and found some promising results, but they need to keep studying to make it even better.
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Hearing impairment affects ∼460 million people worldwide. Conservative therapies, such as hearing aids, bone conduction systems, and middle ear implants, do not always sufficiently compensate for this deficit. The optical stimulation is currently under investigation as an alternative stimulation strategy for the activation of the hearing system.

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Inner hair cell (IHC) Ca1.3 Ca channels are multifunctional channels mediating Ca influx for exocytosis at ribbon synapses, the generation of Ca action potentials in pre-hearing IHCs and gene expression. IHCs of deaf systemic Ca1.

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Pressure sensitive adhesives based on silicone materials are used particularly for skin adhesion, e.g., the fixation of electrocardiogram (ECG) electrodes or wound dressings.

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Background: Therapeutic drug monitoring (TDM) of antidepressants is important to ensure compliance and to rule out pharmacokinetic abnormalities. Therefore, reliable methods for quantification are important for clinical laboratories. Most of the currently used mass spectrometry methods use triple quadrupoles as mass analyzers.

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Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require surgery with limited locations for device attachment.

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Acute myeloid leukemia (AML) arises through clonal expansion of transformed myeloid progenitor cells. The proto-oncogene is highly upregulated in different solid tumors and leukemic cells, but little is known about its transcriptional regulation during leukemogenesis. MYB is an important hematopoietic transcription factor involved in proliferation as well as differentiation and upregulated in most human acute leukemias.

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