Publications by authors named "Katharina Passecker"
Saliva based diagnostics is a rapidly evolving field due to the large diagnostic potential and simple sample collection. Currently only few individual molecules were investigated for their diagnostic capabilities in saliva. A systematic comparison of IgG antibody profiles in saliva and plasma is still missing in scientific literature.
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- HuR is an RNA-binding protein linked to immune regulation and certain cancers, particularly colorectal cancer, by stabilizing mRNAs that promote tumor growth and inflammation.
- The study found increased levels of HuR in colonic epithelial cells from patients with IBD, FAP, and colorectal cancer, while a small-molecule inhibitor of HuR, MS-444, worsened conditions in a model of IBD but reduced tumors in a FAP model.
- These findings suggest that HuR plays a crucial role at different stages of colorectal cancer development, indicating potential for HuR inhibition as a preventive strategy for FAP, but caution is needed in patients with IBD.