Microparticles for drug delivery based on functional polycaprolactones with enhanced degradability: loading of hydrophilic and hydrophobic active compounds.

Microparticle drug carriers made of biodegradable functional polyesters were produced. The polyesters consist of a poly(ε-caprolactone) backbone bearing pendant acryloyloxy and methacryloyloxy groups. Stable microparticles were prepared via an oil/water emulsion-solvent evaporation technique eventually combined with a simultaneous crosslinking procedure.

Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application.

The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and the prolonged drug release. The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLLA) nanoparticles as drug carriers to prevent restenotic processes after stent implantation. The average 250 nm sized 20%(w/w) sirolimus-loaded nanoparticles were extensively characterized with regard to in vitro degradation, biocompatibility and in vitro drug release.