Publications by authors named "Katharina Kotschnew"
Article Synopsis
- The study investigates the role of endosomal SNARE proteins Vti1a and Vti1b in neuronal development, highlighting their importance for membrane fusion and neurite outgrowth.
- In a mouse model and using CRISPR/Cas9, the researchers created a double knockout of these proteins in neuroblastoma cells, which showed impaired differentiation and reduced neurite formation compared to normal cells.
- The findings indicate that the absence of these SNARE proteins hinders critical signaling pathways involved in neurite elongation, specifically affecting responses to neurotrophic factors and signaling cascades like Akt and Erk.
Background: Neurons are highly specialized cells with a complex morphology generated by various membrane trafficking steps. They contain Golgi outposts in dendrites, which are formed from somatic Golgi tubules. In trafficking membrane fusion is mediated by a specific combination of SNARE proteins.
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