Assessment of wound healing efficacy and tolerability using CicatrylTM cream based on a suction blister model in healthy subjects.

Background: CicatrylTM cream, a topical medical device, is indicated for the treatment of superficial wounds and small skin injuries.

Objectives: To assess the efficacy and tolerability of CicatrylTM cream by measuring the recovery of the skin barrier after inducing wounds.

Materials & Methods: A suction blister of about 6-mm diameter was induced on the inner side of each forearm of 44 healthy subjects.

Topical Film-Forming Solid Solutions for Enhanced Dermal Delivery of the Retinoid Tazarotene.

Topical film-forming solutions (FFSs) show considerable potential for dermal delivery of an API. Through a mechanism of in situ film formation upon solvent evaporation, they may improve skin delivery by prolonging substantivity on the skin, by establishing a transient supersaturation, and/or by enhancing solubility through the formation of a solid dispersion in the resulting film. This work aimed at developing an FFS for topical application with enhanced skin delivery.