Publications by authors named "Katharina Hammerschmidt"
Several studies have demonstrated, both in vitro and in animal models, the anti-tumor efficacy of high-dose ascorbate treatment against a variety of tumor entities, including glioblastoma, the most common and aggressive primary malignant brain tumor. The aim of this study was to investigate the effects of high-dose ascorbate as well as dehydroascorbic acid on human glioblastoma cell lines and to evaluate different treatment conditions for the combined administration of ascorbate with magnesium (Mg) and iron (Fe). Intracellular levels of reactive oxygen species and the induction of cell death following ascorbate treatment were also investigated.
View Article and Find Full Text PDFArticle Synopsis
- Bone cells produce FGF23, a hormone that helps regulate phosphate and vitamin D levels, with elevated FGF23 linked to chronic kidney disease and cardiovascular issues.
- The study examined how Prostaglandin E (PGE), particularly through its receptor EP2, influences FGF23 production in bone cells, and found that PGE significantly enhances FGF23 levels.
- Using different mouse models, the research showed that PGE signaling through EP2 and the transcription factor Nurr1 is critical for FGF23 production, suggesting potential clinical implications for conditions involving inflammation and kidney health.
Introduction: Fibroblast growth factor 23 (FGF23) is a major regulator of phosphate and vitamin D metabolism in the kidney, and its higher levels in plasma are associated with poorer outcomes in kidney and cardiovascular diseases. It is produced by bone cells upon enhanced oxidative stress and inhibits renal phosphate reabsorption and calcitriol (active form of vitamin D) production. Bilirubin, the final product of the heme catabolic pathway in the vascular bed, has versatile biological functions, including antioxidant and anti-inflammatory effects.
View Article and Find Full Text PDF